The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression
Abstract
The oncogene MYCN is critical for tumorigenesis of several types of cancers including neuroblastoma. We previously reported that miR-506-3p repressed MYCN expression in neuroblastoma cells. However, the mechanism underlying such regulation was undetermined since there is no miR-506-3p target site in MYCN 3’UTR.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 22, 2020
- Source ID
- 10.1186/s13046-020-1531-2
Entities
People
- Alejandro Oviedo
- Amy L. Baker
- Collin P. Bryant
- Liqin Du
- Soroush Omidvarnia
- Spencer D. Shelton
- Zhenze Zhao
Organizations
- United States Department of Defense