Patient-derived cell lines and orthotopic mouse model of peritoneal carcinomatosis recapitulate molecular and phenotypic features of human gastric adenocarcinoma
Abstract
Gastric adenocarcinoma with peritoneal carcinomatosis (PC) is therapy resistant and leads to poor survival. To study PC in depth, there is an urgent need to develop representative PC-derived cell lines and metastatic models to study molecular mechanisms of PC and for preclinical screening of new therapies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 23, 2021
- Source ID
- 10.1186/s13046-021-02003-8
Entities
People
- Ailing W. Scott
- Brian D. Badgwell
- Jaffer Ajani
- Jiankang Jin
- Kazuto Harada
- Lang Ma
- Linghua Wang
- Longfei Huo
- Melissa Pool Pizzi
- Namita D. Shanbhag
- Qiong Gan
- Ruiping Wang
- Shuangtao Zhao
- Shumei Song
- Sinchita Roy-chowdhuri
- Xiaodan Yao
- Yan Xu
- Yibo Fan
- Ying Wang
- Yuan Li
- Zhenning Wang
Organizations
- National Cancer Institute
- National Institutes of Health