Unshrinking the baby lung to calm the VILI vortex
Abstract
A hallmark of ARDS is progressive shrinking of the ‘baby lung,’ now referred to as the ventilator-induced lung injury (VILI) ‘vortex.’ Reducing the risk of the VILI vortex is the goal of current ventilation strategies; unfortunately, this goal has not been achieved nor has mortality been reduced. However, the temporal aspects of a mechanical breath have not been considered. A brief expiration prevents alveolar collapse, and an extended inspiration can recruit the atelectatic lung over hours. Time-controlled adaptive ventilation (TCAV) is a novel ventilator approach to achieve these goals, since it considers many of the temporal aspects of dynamic lung mechanics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 07, 2022
- Source ID
- 10.1186/s13054-022-04105-x
Entities
People
- Auyon Ghosh
- David W. Kaczka
- Donald Gaver
- Gary F Nieman
- Harry Ramcharran
- Jason Bates
- Joshua Satalin
- Louis A. Gatto
- Michaela Kollisch-Singule
- Nader M. Habashi
- Penny Andrews
- Sarah Blair
Organizations
- Congressionally Directed Medical Research Programs
- National Heart, Lung, and Blood Institute