CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer
Abstract
CGRRF1 is a growth suppressor and consists of a transmembrane domain and a RING-finger domain. It functions as a RING domain E3 ubiquitin ligase involved in endoplasmic reticulum-associated degradation. The expression of CGRRF1 is decreased in cancer tissues; however, the role of CGRRF1 in breast cancer and the mechanism(s) of its growth suppressor function remain to be elucidated.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2019
- Source ID
- 10.1186/s13058-019-1212-2
Entities
People
- Joshua D. Graves
- Shiuh-Rong Ho
- Shixia Huang
- Weei-Chin Lin
- Yang Xiao
- Yu-Ju Lee
Organizations
- Cancer Prevention and Research Institute of Texas
- National Cancer Institute
- National Institutes of Health
- United States Department of Defense