Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach
Abstract
Extracellular vesicles (EVs) are small membrane particles that contribute to cancer progression and metastases by transporting biologically significant proteins and nucleic acids. They may also serve as biomarkers of various disease states or important therapeutic targets. Breast cancer EVs have the potential to change the behavior of other cells in their microenvironment. However, the proteomic content of EVs isolated from young women’s breast cancer patients and the mechanisms underlying the influence of EVs on tumor cell behavior have not yet been reported.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 23, 2020
- Source ID
- 10.1186/s13058-020-01363-x
Entities
People
- Jenny J. Xian
- Jessica K. Hall
- Kimberly R Jordan
- Kirk C Hansen
- Michelle Borakove
- Monika Dzieciatkowska
- Pepper J Schedin
- Traci R. Lyons
- Troy Schedin
- Virginia F Borges
Organizations
- American Association for Cancer Research
- David F. and Margaret T. Grohne Family Foundation
- National Cancer Institute
- National Center for Research Resources
- United States Department of Defense