Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ: results from the EPIC-Heidelberg cohort
Abstract
Experimental and epidemiological studies demonstrate a role for 27-hydroxycholesterol (27HC) in breast cancer development, though results are conflicting. Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERβ) may impact the association between 27HC and breast cancer risk.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 19, 2020
- Source ID
- 10.1186/s13058-020-1253-6
Entities
People
- Britta Walter
- Charlotte Le Cornet
- Disorn Sookthai
- Ester Herpel
- Renée Turzanski Fortner
- Rudolf Kaaks
- Theron S. Johnson
- Tilman Kühn
Organizations
- Federal Ministry of Research, Technology and Space
- Office Of The Under Secretary Of Defense