The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer
Abstract
Breast cancer (BC) is the most common cancer in women and the leading cause of cancer-associated mortality in women. In particular, triple-negative BC (TNBC) has the highest rate of mortality due in large part to the lack of targeted treatment options for this subtype. Thus, there is an urgent need to identify new molecular targets for TNBC treatment. RALA and RALB are small GTPases implicated in growth and metastasis of a variety of cancers, although little is known of their roles in BC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 12, 2021
- Source ID
- 10.1186/s13058-021-01438-3
Entities
People
- Alo Ray
- Arnab Chakravarti
- Arthur W. Lian
- Cynthia D. Timmers
- Dillon S. Richardson
- Gina M. Sizemore
- Jonathan M Spehar
- Katie A. Thies
- Manjusri Das
- Matthew W. Cole
- Michael C. Ostrowski
- Rachel E. Schafer
- Reena Shakya
- Sarah A. Steck
- Steven T Sizemore
- Sue E. Knoblaugh
Organizations
- National Cancer Institute
- United States Department of Defense