STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment
Abstract
In breast cancer, complex interactions between tumor cells and cells within the surrounding stroma, such as macrophages, are critical for tumor growth, progression, and therapeutic response. Recent studies have highlighted the complex nature and heterogeneous populations of macrophages associated with both tumor-promoting and tumor-inhibiting phenotypes. Defining the pathways that drive macrophage function is important for understanding their complex phenotypes within the tumor microenvironment. Signal transducer and activator of transcription (STAT) transcription factors, such as STAT5, are key regulators of immune cell function. The studies described here investigate the functional contributions of STAT5 to tumor-associated macrophage function in breast cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 07, 2021
- Source ID
- 10.1186/s13058-021-01481-0
Entities
People
- Christine H. O’connor
- Danielle N. Huggins
- Emily A. Jesser
- Kathryn L Schwertfeger
- Nicholas J. Brady
- Patrice M. Witschen
Organizations
- American Cancer Society
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Cancer Institute
- National Institutes of Health
- United States Department of Defense