Elevated NRAS expression during DCIS is a potential driver for progression to basal-like properties and local invasiveness
Abstract
Ductal carcinoma in situ (DCIS) is the most common type of in situ premalignant breast cancers. What drives DCIS to invasive breast cancer is unclear. Basal-like invasive breast cancers are aggressive. We have previously shown that NRAS is highly expressed selectively in basal-like subtypes of invasive breast cancers and can promote their growth and progression. In this study, we investigated whether NRAS expression at the DCIS stage can control transition from luminal DCIS to basal-like invasive breast cancers.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 18, 2022
- Source ID
- 10.1186/s13058-022-01565-5
Entities
People
- Bing Zhang
- Eric C. Chang
- Fariba Behbod
- Flora Lo
- Hanan Elsarraj
- Hilda Kennedy
- Jonathan T. Lei
- Long Feng
- Meenakshi Anurag
- Ossama W. Tawfik
- Xiang H-F Zhang
- Yan Hong
- Yichao Shen
- Ze-yi Zheng
- Zifan Zhao
Organizations
- Cancer Prevention and Research Institute of Texas
- Cancer Research UK
- National Institutes of Health
- United States Department of Defense