Hemispheric asymmetry in the human brain and in Parkinson’s disease is linked to divergent epigenetic patterns in neurons
Abstract
Hemispheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives symptom lateralization in Parkinson’s disease (PD), but its molecular determinants are unknown. Here, we identify divergent epigenetic patterns involved in hemispheric asymmetry by profiling DNA methylation in isolated prefrontal cortex neurons from control and PD brain hemispheres. DNA methylation is fine-mapped at enhancers and promoters, genome-wide, by targeted bisulfite sequencing in two independent sample cohorts.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 09, 2020
- Source ID
- 10.1186/s13059-020-01960-1
Entities
People
- Elizabeth Ensink
- Irving Vega
- Jared Lamp
- Lee Marshall
- Meghan Schilthuis
- Peipei Li
- Sean Lang
- Viviane Labrie
Organizations
- National Institutes of Health
- United States Department of Defense