Cluster identification, selection, and description in cluster randomized crossover trials: the PREP-IT trials
Abstract
In cluster randomized crossover (CRXO) trials, groups of participants (i.e., clusters) are randomly allocated to receive a sequence of interventions over time (i.e., cluster periods). CRXO trials are becoming more comment when they are feasible, as they require fewer clusters than parallel group cluster randomized trials. However, CRXO trials have not been frequently used in orthopedic fracture trials and represent a novel methodological application within the field. To disseminate the early knowledge gained from our experience initiating two cluster randomized crossover trials, we describe our process for the identification and selection of the orthopedic practices (i.e., clusters) participating in the PREP-IT program and present data to describe their key characteristics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 12, 2020
- Source ID
- 10.1186/s13063-020-04611-9
Entities
People
- Amber Wood
- Anthony D. Harris
- Christina Boulton
- David Pogorzelski
- Ernesto Guerra-farfán
- Francesc Marcano-fernández
- Gerard P Slobogean
- Greg Gaski
- Joan Hebden
- Lehana Thabane
- Lyndsay M. O'hara
- Mohit Bhandari
- On Behalf Of The Prep-it Investigators
- Paula Mckay
- Samir Mehta
- Shannon Dodds
- Sheila Sprague
- Taryn Scott
Organizations
- Canadian Institutes of Health Research
- McMaster University
- Patient-Centered Outcomes Research Institute
- Physicians' Services Incorporated Foundation
- United States Department of Defense