Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi
Abstract
The most common apicomplexan parasites causing bovine babesiosis are Babesia bovis and B. bigemina, while B. caballi and Theileria equi are responsible for equine piroplasmosis. Treatment and control of these diseases are usually achieved using potentially toxic chemotherapeutics, such as imidocarb diproprionate, but drug-resistant parasites are emerging, and alternative effective and safer drugs are needed. The endochin-like quinolones (ELQ)-300 and ELQ-316 have been proven to be safe and efficacious against related apicomplexans, such as Plasmodium spp., with ELQ-316 also being effective against Babesia microti, without showing toxicity in mammals.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2020
- Source ID
- 10.1186/s13071-020-04487-3
Entities
People
- Aaron Nilsen
- Carlos E. Suarez
- J Stone Doggett
- Marta G. Silva
- Michael K. Riscoe
- Reginaldo G. Bastos
- Rolf Winter
- Rozalia A Dodean
- Sovitj Pou
Organizations
- Agricultural Research Service
- International Development Research Centre
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- United States Department of Defense
- United States Department of Veterans Affairs