Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types
Abstract
The T cell-inflamed tumor microenvironment, characterized by CD8 T cells and type I/II interferon transcripts, is an important cancer immunotherapy biomarker. Tumor mutational burden (TMB) may also dictate response, and some oncogenes (i.e., WNT/β-catenin) are known to mediate immunosuppression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 27, 2020
- Source ID
- 10.1186/s13073-020-00787-6
Entities
People
- Daniel Stapor
- Jason J Luke
- Riyue Bao
Organizations
- United States Department of Defense