An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility
Abstract
While genome-wide associations studies (GWAS) have successfully elucidated the genetic architecture of complex human traits and diseases, understanding mechanisms that lead from genetic variation to pathophysiology remains an important challenge. Methods are needed to systematically bridge this crucial gap to facilitate experimental testing of hypotheses and translation to clinical utility.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 17, 2021
- Source ID
- 10.1186/s13073-021-00904-z
Entities
People
- Alejandro L. Antonia
- Andy Ingham
- Christopher W Woods
- Dennis C Ko
- Elizabeth R. Hauser
- Emily R. Ko
- Ephraim L Tsalik
- Florica J. Constantine
- Geoffrey S Ginsburg
- Liuyang Wang
- Mark R. Delong
- Micah T McClain
- Ricardo Henao
- Thomas J. Balmat
- Thomas W. Burke
- Xiling Shen
Organizations
- Defense Advanced Research Projects Agency
- National Institute of Allergy and Infectious Diseases