Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2
Abstract
The emergence of SARS-CoV-2 underscores the need to better understand the evolutionary processes that drive the emergence and adaptation of zoonotic viruses in humans. In the betacoronavirus genus, which also includes SARS-CoV and MERS-CoV, recombination frequently encompasses the receptor binding domain (RBD) of the Spike protein, which is responsible for viral binding to host cell receptors. In this work, we reconstruct the evolutionary events that have accompanied the emergence of SARS-CoV-2, with a special emphasis on the RBD and its adaptation for binding to its receptor, human ACE2.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 06, 2021
- Source ID
- 10.1186/s13073-021-00943-6
Entities
People
- Costas D. Maranas
- Ioan Filip
- Juan Ángel Patiño-galindo
- Mohammed AlQuraishi
- Peter K. Sorger
- Ratul Chowdhury
- Raúl Rabadán
Organizations
- Defense Advanced Research Projects Agency
- National Institutes of Health