Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers

Abstract

African ancestry is a significant risk factor for advanced prostate cancer (PCa). Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the region has largely been excluded from the benefits of whole genome interrogation studies. Additionally, while structural variation (SV) is highly prevalent, PCa genomic studies are still biased towards small variant interrogation.

Document Details

Document Type
Pub Defense Publication
Publication Date
Aug 31, 2022
Source ID
10.1186/s13073-022-01096-w

Entities

People

  • Anne-maree Haynes
  • Anthony T. Papenfuss
  • Cali Willet
  • Eva K. F. Chan
  • Gabriela Pasqualim
  • Ilma Simoni Brum
  • Jue Jiang
  • Phillip D. Stricker
  • Riana M. S. Bornman
  • Rosemarie Sadsad
  • Ruth J. Lyons
  • Sean M. Patrick
  • Shingai B. A. Mutambirwa
  • Tingting Gong
  • Tracy Chew
  • Vanessa Hayes
  • Weerachai Jaratlerdsiri

Organizations

  • National Health and Medical Research Council
  • University of Sydney

Tags

Readers

  • Molecular and genetic basis of cancer.
  • Oncology and Biomarker-Based Cancer Detection.
  • Seismology