A one-year genomic investigation of Escherichia coli epidemiology and nosocomial spread at a large US healthcare network
Abstract
Extra-intestinal pathogenicEscherichia coli(ExPEC) are a leading cause of bloodstream and urinary tract infections worldwide. Over the last two decades, increased rates of antibiotic resistance inE. colihave been reported, further complicating treatment. Worryingly, specific lineages expressing extended-spectrumβ-lactamases (ESBLs) and fluoroquinolone resistance have proliferated and are now considered a serious threat. Obtaining contemporary information on the epidemiology and prevalence of these circulating lineages is critical for containing their spread globally and within the clinic.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 30, 2022
- Source ID
- 10.1186/s13073-022-01150-7
Entities
People
- Ana C. Ong
- Brendan W. Corey
- Casey Harless
- Emma G. Mills
- François Lebreton
- Jason W. Bennett
- Joshua A. Rosado-mendez
- Lan N. Preston
- Melissa J. Martin
- Michael G. Backlund
- Patrick T. Mc Gann
- Rosslyn Maybank
- Scott B. Preston
- Ting L. Luo
- Yoon I. Kwak
Organizations
- Armed Forces Health Surveillance Center