Methylated markers accurately distinguish primary central nervous system lymphomas (PCNSL) from other CNS tumors
Abstract
Definitive diagnosis of primary central nervous system lymphoma (PCNSL) requires invasive surgical brain biopsy, causing treatment delays. In this paper, we identified and validated tumor-specific markers that can distinguish PCNSL from other CNS tumors in tissues. In a pilot study, we tested these newly identified markers in plasma.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 05, 2021
- Source ID
- 10.1186/s13148-021-01091-9
Entities
People
- Bradley M. Downs
- Chetan Bettegowda
- Christopher B Umbricht
- Huihua He
- Leslie M. Cope
- Matthias Holdhoff
- Saraswati Sukumar
- Wanjun Ding
- Weiping Tao
- Wenge Li
- Xiaokang Ke
Organizations
- National Institutes of Health
- United States Department of Defense