Association of peripheral blood DNA methylation level with Alzheimer’s disease progression

Abstract

Identifying biomarkers associated with Alzheimer’s disease (AD) progression may enable patient enrichment and improve clinical trial designs. Epigenome-wide association studies have revealed correlations between DNA methylation at cytosine-phosphate-guanine (CpG) sites and AD pathology and diagnosis. Here, we report relationships between peripheral blood DNA methylation profiles measured using Infinium® MethylationEPIC BeadChip and AD progression in participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Oct 15, 2021
• Source ID: 10.1186/s13148-021-01179-2

Entities

People

• Andrew J. Saykin
• Aparna Vasanthakumar
• For The Alzheimer’s Disease Neuroimaging Initiative (adni)
• Jeffrey F. Waring
• Justin W. Davis
• Kenneth B. Idler
• Kwangsik Nho
• Qingqin S Li

Organizations

• Alzheimer's Disease Neuroimaging Initiative

Tags

Fields of Study

• Biology

Readers

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