A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources
Abstract
Myeloid-derived suppressor cells (MDSCs), which include monocytic (mMDSCs) and granulocytic (gMDSCs) cells, are an immunosuppressive, heterogeneous population of cells upregulated in cancer and other pathologic conditions, in addition to normal conditions of stress. The origin of MDSCs is debated, and the regulatory pattern responsible for gMDSC differentiation remains unknown. Since DNA methylation (DNAm) contributes to lineage differentiation, we have investigated whether it contributes to the acquisition of the gMDSC phenotype.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 21, 2022
- Source ID
- 10.1186/s13148-022-01247-1
Entities
People
- Annette M Molinaro
- Brock C Christensen
- Devin C Koestler
- Emily Nissen
- Isabella Berglund-brown
- James F. Padbury
- John K Wiencke
- Karl Kelsey
- Lucas A. Salas
- Melissa N. Eliot
- Rondi A. Butler
Organizations
- Foundation for the National Institutes of Health
- National Cancer Institute
- National Institute of General Medical Sciences
- United States Department of Defense