Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages
Abstract
There is considerable evidence that epigenetic mechanisms and DNA methylation are critical drivers of immune cell lineage differentiation and activation. However, there has been limited coordinated investigation of common epigenetic pathways among cell lineages. Further, it remains unclear if long-lived memory cell subtypes differentiate distinctly by cell lineages.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2022
- Source ID
- 10.1186/s13148-022-01399-0
Entities
People
- Annette M Molinaro
- Brock C Christensen
- Devin C Koestler
- Gayathri Warrier
- John K Wiencke
- Karl Kelsey
- Lucas A. Salas
- Rondi A. Butler
- Shelby Bell-glenn
- Ze Zhang
Organizations
- American Association for Cancer Research
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institutes of Health
- United States Department of Defense