Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics
Abstract
Oncogenic overexpression of integrin-β7 (ITGB7) in cases of high-risk multiple myeloma (MM) was reported to promote enhanced interactions between neoplastic plasma-B cells and stromal cells to develop cell-adhesion mediated drug resistance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 04, 2023
- Source ID
- 10.1186/s13148-023-01433-9
Entities
People
- Alan J Tackett
- Cody Ashby
- Duah Alkam
- Fenghuang Zhan
- Frits Van Rhee
- Samrat Roy Choudhury
- Stephanie D. Byrum
Organizations
- National Cancer Institute
- National Institute of General Medical Sciences
- United States Department of Defense