Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study
Abstract
Current methods of amyloid PET interpretation based on the binary classification of global amyloid signal fail to identify early phases of amyloid deposition. A recent analysis of 18F-florbetapir PET data from the Alzheimer’s disease Neuroimaging Initiative cohort suggested a hierarchical four-stage model of regional amyloid deposition that resembles neuropathologic estimates and can be used to stage an individual’s amyloid burden in vivo. Here, we evaluated the validity of this in vivo amyloid staging model in an independent cohort of older people with subjective memory complaints (SMC). We further examined its potential association with subtle cognitive impairments in this population at elevated risk for Alzheimer’s disease (AD).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 31, 2019
- Source ID
- 10.1186/s13195-019-0466-3
Entities
People
- Amira Saidi
- Andrea Duggento
- Andrea Vergallo
- Antonio Santos
- Arun L W Bokde
- Augusto Claudio Cuello
- Aurélie Kas
- Bruno Dubois
- Catherine Poisson
- Christian Neri
- Christiane Metzinger
- Claudio Babiloni
- Craig Ritchie
- Cristina-maria Coman
- Emiliano Santarnecchi
- Enrica Cavedo
- Erfan Younesi
- Eric Karran
- Fanny Mochel
- Fatemah A Sakr
- Filippo Baldacci
- Filippo S. Giorgi
- For The Insight-pread Study Group
- Foudil Lamari
- Francesco Cacciola
- Francesco Garaci
- Francis Nyasse
- Francis Nyasse-messene
- Gabriel Gonzalez-escamilla
- Geoffroy Gagliardi
- George Perry
- Habib Benali
- Harald Hampel
- Herman Depypere
- Hovagim Bakardjian
- Howard Federoff
- Hugo Bertin
- Irina Jelistratova
- Janet Woodcock
- Jean Lorenceau
- Jean-christophe Corvol
- Jeffrey L. Cummings
- Joel Bonheur
- Juan Castrillo
- Karl Broich
- Karl Herholz
- Katia Santos Andrade
- Katrine Rojkova
- Keith L. Black
- Laurie Boukadida
- Lindsay A. Welikovitch
- Lisi Flores Aguilar
- Lon S. Schneider
- Manuela Graziani
- Marcel Levy
- Maria Teresa Ferretti
- Marie Revillon
- Marie-claude Potier
- Marie-odile Habert
- Marine Sole
- Marion Dubois
- Marion Haberkamp
- Marion Houot
- Mark Mapstone
- Martin Dyrba
- Massimo Fiandaca
- Maxime Locatelli
- Maya Koronyo-hamaoui
- Michel J. Grothe
- Michel Thiebaud De Schotten
- Mohmed Surtee
- Nadia Boukerrou
- Nadjia Younsi
- Nathalie George
- Nicola Toschi
- Nicolas Villain
- Norbert Benda
- Olaf Sporns
- Olivier Colliot
- Patrizia A. Chiesa
- Patrizia Chiesa
- Remy Genthon
- René S. Bun
- Richard A. Frank
- Robert Nisticò
- Roberto Ceravolo
- Seung H. Kim
- Sid E. O'bryant
- Simone Lista
- Simone Rossi
- Stanley Durrleman
- Stefan J Teipel
- Stephane Lehericy
- Steven R. Verdooner
- Stéphane Epelbaum
- The Alzheimer Precision Medicine Initiative (apmi)
- Todd Langevin
- Ubaldo Bonuccelli
- Valentina Escott-price
- Yosef Koronyo
Organizations
- United States Department of Defense