Nonlinear changes in delayed functional network topology in Alzheimer’s disease: relationship with amyloid and tau pathology
Abstract
Alzheimer’s disease is a neurodegenerative disorder associated with the abnormal deposition of pathological processes, such as amyloid-ß and tau, which produces nonlinear changes in the functional connectivity patterns between different brain regions across the Alzheimer’s disease continuum. However, the mechanisms underlying these nonlinear changes remain largely unknown. Here, we address this question using a novel method based on temporal or delayed correlations and calculate new whole-brain functional networks to tackle these mechanisms.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 16, 2023
- Source ID
- 10.1186/s13195-023-01252-3
Entities
People
- Anna Canal-garcia
- Dániel Veréb
- For The Alzheimer’s Disease Neuroimaging Initiative*
- Giovanni Volpe
- Joana B. Pereira
- Mite Mijalkov
- Thomas Hinault
Organizations
- Karolinska Institutet