TSG-6 in conditioned media from adipose mesenchymal stem cells protects against visual deficits in mild traumatic brain injury model through neurovascular modulation
Abstract
Retinal inflammation affecting the neurovascular unit may play a role in the development of visual deficits following mild traumatic brain injury (mTBI). We have shown that concentrated conditioned media from adipose tissue-derived mesenchymal stem cells (ASC-CCM) can limit retinal damage from blast injury and improve visual function. In this study, we addressed the hypothesis that TNFα-stimulated gene-6 (TSG-6), an anti-inflammatory protein released by mesenchymal cells, mediates the observed therapeutic potential of ASCs via neurovascular modulation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 05, 2019
- Source ID
- 10.1186/s13287-019-1436-1
Entities
People
- Anton Reiner
- Chuan He Yang
- Jordy Gentry
- Kumar Abhiram Jha
- Lada Klaic
- Lawrence M Pfeffer
- Mickey Pentecost
- Nicolas Sohl
- Nobel Del Mar
- Rajashekhar Gangaraju
- Raji Lenin
Organizations
- National Eye Institute
- United States Department of Defense