Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems
Abstract
Billions of dollars are invested annually by pharmaceutical companies in search of new options for treating hair loss conditions; nevertheless, the challenge remains. One major limitation to hair follicle research is the lack of effective and efficient drug screening systems using human cells. Organoids, three-dimensional in vitro structures derived from stem cells, provide new opportunities for studying organ development, tissue regeneration, and disease pathogenesis. The present study focuses on the formation of human hair follicle organoids.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2019
- Source ID
- 10.1186/s13287-019-1504-6
Entities
People
- Chang Liu
- Chuan Ma
- Jie Wen
- Junrong Zhu
- Qun Zhang
- Xin Xu
- Xunwei Wu
- Yiqun Su
- Zhiwei Xie
Organizations
- U.S. Military HIV Research Program