Characterization of traumatized muscle-derived multipotent progenitor cells from low-energy trauma
Abstract
Multipotent progenitor cells have been harvested from different human tissues, including the bone marrow, adipose tissue, and umbilical cord blood. Previously, we identified a population of mesenchymal progenitor cells (MPCs) isolated from the traumatized muscle of patients undergoing reconstructive surgery following a war-related blast injury. These cells demonstrated the ability to differentiate into multiple mesenchymal lineages. While distal radius fractures from a civilian setting have a much lower injury mechanism (low-energy trauma), we hypothesized that debrided traumatized muscle near the fracture site would contain multipotent progenitor cells with the ability to differentiate and regenerate the injured tissue.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 06, 2021
- Source ID
- 10.1186/s13287-020-02038-2
Entities
People
- Alexander Dimtchev
- Christopher Daniels
- Jaira F de Vasconcellos
- John C. Dunn
- Leon J. Nesti
- Marvin E Dingle
- Sonia Zicari
- Stephen D. Fernicola