Extracellular vesicle mimics made from iPS cell-derived mesenchymal stem cells improve the treatment of metastatic prostate cancer
Abstract
Extracellular vesicles (EVs) and their mimics from mesenchymal stem cells (MSCs) are promising drug carriers to improve cancer treatment, but their application is hindered by donor variations and expansion limitations of conventional tissue-derived MSCs. To circumvent these issues, we made EV-mimicking nanovesicles from standardized MSCs derived from human induced pluripotent stem cells (iPSCs) with a theoretically limitless expandability, and examined the targeting capacity of these nanovesicles to prostate cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 07, 2021
- Source ID
- 10.1186/s13287-020-02097-5
Entities
People
- Bo Hai
- Fei Liu
- Jack Kelly
- Qingguo Zhao
- Samuel Wu