Use of constitutive and inducible oncogene-containing iPSCs as surrogates for transgenic mice to study breast oncogenesis
Abstract
Powerful constitutive and inducible transgenic / bitransgenic / tritransgenic murine models of breast cancer have been used over the past two decades to shed light on the molecular mechanisms by which the given transgenic oncogenes have interacted with other cellular genes and set in motion breast cancer initiation and progression. However, these transgenic models, as in vivo models only, are expensive and restrictive in the opportunities they provide to manipulate the experimental variables that would enable a better understanding of the molecular events related to initial transformation and the target cell being transformed.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 27, 2021
- Source ID
- 10.1186/s13287-021-02285-x
Entities
People
- Arnav P. Modi
- Christine T Nguyen
- Dörthe Schaue
- Ihsaan Ahmad
- Julie P. T. Nguyen
- Sabrina R. Wilhelm
- Sanford H. Barsky
- Sarah C. Petrova
- Stuart D. Ferrell Jr.
- Yin Ye
Organizations
- United States Army Materiel Command
- University of California