ASCs derived from burn patients are more prone to increased oxidative metabolism and reactive oxygen species upon passaging
Abstract
Patients with severe burn injury (over 20% of the total body surface area) experience profound hypermetabolism which significantly prolongs wound healing. Adipose-derived stem cells (ASCs) have been proposed as an attractive solution for treating burn wounds, including the potential for autologous ASC expansion. While subcutaneous adipocytes display an altered metabolic profile post-burn, it is not known if this is the case with the stem cells associated with the adipose tissue.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 06, 2021
- Source ID
- 10.1186/s13287-021-02327-4
Entities
People
- Belinda I. Gómez
- David M Burmeister
- Grace Chu-yuan Chu
- Linda E. Sousse
- Robert J Christy
- Shanmugasundaram Natesan
- Tiffany C. Heard
- Tony Chao
Organizations
- United States Army Medical Research and Development Command