Culture and characterization of various porcine integumentary-connective tissue-derived mesenchymal stromal cells to facilitate tissue adhesion to percutaneous metal implants
Abstract
Transdermal osseointegrated prosthesis have relatively high infection rates leading to implant revision or failure. A principle cause for this complication is the absence of a durable impervious biomechanical seal at the interface of the hard structure (implant) and adjacent soft tissues. This study explores the possibility of recapitulating an analogous cellular musculoskeletal-connective tissue interface, which is present at naturally occurring integumentary tissues where a hard structure exits the skin, such as the nail bed, hoof, and tooth.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 18, 2021
- Source ID
- 10.1186/s13287-021-02666-2
Entities
People
- Andrea H. Dragon
- Cole J. Homer
- Conrado Aparicio
- David T. Danielson
- Devaveena Dey
- Elsa Ronzier
- Isha Mutreja
- Joan E. Bechtold
- Jonathan A. Forsberg
- Nicholas G. Fischer
- Thomas A. Davis