Epimorphic regeneration of the mouse digit tip is finite
Abstract
Structural regeneration of amputated appendages by blastema-mediated, epimorphic regeneration is a process whose mechanisms are beginning to be employed for inducing regeneration. While epimorphic regeneration is classically studied in non-amniote vertebrates such as salamanders, mammals also possess a limited ability for epimorphic regeneration, best exemplified by the regeneration of the distal mouse digit tip. A fundamental, but still unresolved question is whether epimorphic regeneration and blastema formation is exhaustible, similar to the finite limits of stem-cell mediated tissue regeneration.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 07, 2022
- Source ID
- 10.1186/s13287-022-02741-2
Entities
People
- Alyssa Falck
- Benjamin Daniel
- Connor P. Dolan
- Dana Gaddy
- Felisha Imholt
- Hannah Koester
- Joshua Gregory
- Katherine Zimmel
- Kayla Ritchie
- Ken Muneoka
- Larry J Suva
- Lindsay A Dawson
- Ling Yu
- Macie Mayes
- Mingquan Yan
- Osama Qureshi
- Regina Brunauer
- Tae-jung Yang
Organizations
- Defense Advanced Research Projects Agency
- Texas A&M University
- Tulane University of Louisiana