Modeling oxidative injury response in human kidney organoids
Abstract
Hemolysis occurs in many injury settings and can trigger disease processes. In the kidney, extracellular hemoglobin can induce damage via several mechanisms. These include oxidative stress, mitochondrial dysfunction, and inflammation, which promote fibrosis and chronic kidney disease. Understanding the pathophysiology of these injury pathways offers opportunities to develop new therapeutic strategies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 21, 2022
- Source ID
- 10.1186/s13287-022-02752-z
Entities
People
- Alan J Davidson
- Amanda E. Crunk
- Aneta Przepiorski
- Cassandra L. Happ
- Catherine J. Baty
- Dave R. Emlet
- Emily Parasky
- Eugenel B. Espiritu
- John A. Kellum
- Lawrence A. Vernetti
- Matthew L. Macdonald
- Michael D. McDaniels
- Neil A Hukriede
- Ryan Salisbury
- Thitinee Vanichapol
- Thomas R. Kleyman
Organizations
- American Society of Nephrology
- National Institute of Diabetes and Digestive and Kidney Diseases
- United States Army