The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells
Abstract
Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to several stimuli including disease, injury, starvation, and normal aging. Currently, there is no truly effective pharmacological therapy for atrophy; therefore, exploration of the mechanisms contributing to atrophy is essential because it will eventually lead to discovery of an effective therapeutic target. The ether-a-go-go related gene (ERG1A) K+ channel has been shown to contribute to atrophy by upregulating ubiquitin proteasome proteolysis in cachectic and unweighted mice and has also been implicated in calcium modulation in cancer cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 16, 2020
- Source ID
- 10.1186/s13395-019-0220-3
Entities
People
- Albert K. Urazaev
- Amber L Pond
- Clayton Whitmore
- Evan P.s. Pratt
- Gregory H. Hockerman
- Judith K. Davie
- Kevin Bradley
- Luke Anderson
- Mariam N. Hashmi
- Rod Weilbaecher
- Sawyer M. Latour
- Wen-horng Wang
Organizations
- Southern Illinois University
- United States Department of Defense