Y chromosome in health and diseases
Abstract
Sex differences are prevalent in normal development, physiology and disease pathogeneses. Recent studies have demonstrated that mosaic loss of Y chromosome and aberrant activation of its genes could modify the disease processes in male biased manners. This mini review discusses the nature of the genes on the human Y chromosome and identifies two general categories of genes: those sharing dosage-sensitivity functions with their X homologues and those with testis-specific expression and functions. Mosaic loss of the former disrupts the homeostasis important for the maintenance of health while aberrant activation of the latter promotes pathogenesis in non-gonadal tissues, thereby contributing to genetic predispositions to diseases in men.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 13, 2020
- Source ID
- 10.1186/s13578-020-00452-w
Entities
People
- Yun-Fai Chris Lau
Organizations
- United States Department of Defense
- United States Department of Veterans Affairs