SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics study
Abstract
Cancer stem cells (CSCs) are the root of human cancer development and the major cause of treatment failure. Aberrant elevation of SOX4, a member of SOX (SRY-related HMG-box) family transcription factors, has been identified in many types of human cancer and promotes cancer development. However, the role of SOX4 in CSCs, especially at a proteome-wide level, has remained elusive. The aim of this study is to investigate the effect of SOX4 on the stemness of CSCs and reveal the underlying mechanisms by identification of SOX4-induced proteome changes through proteomics study.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 22, 2021
- Source ID
- 10.1186/s13578-021-00539-y
Entities
People
- Dong Wang
- Dongling Zou
- Dongyan Ding
- Jiangfeng Qiu
- Jingshu Liu
- Lei Zhou
- Qi Zhou
- Tingyuan Lang
- Yang Zhang
- Yunzhe Li
- Zhiqi Zhang
Organizations
- Chongqing Science and Technology Commission
- National Natural Science Foundation of China
- Office of Naval Research