Exosomes originating from infection with the cytoplasmic single-stranded RNA virus Rift Valley fever virus (RVFV) protect recipient cells by inducing RIG-I mediated IFN-B response that leads to activation of autophagy
Abstract
Although multiple studies have demonstrated a role for exosomes during virus infections, our understanding of the mechanisms by which exosome exchange regulates immune response during viral infections and affects viral pathogenesis is still in its infancy. In particular, very little is known for cytoplasmic single-stranded RNA viruses such as SARS-CoV-2 and Rift Valley fever virus (RVFV). We have used RVFV infection as a model for cytoplasmic single-stranded RNA viruses to address this gap in knowledge. RVFV is a highly pathogenic agent that causes RVF, a zoonotic disease for which no effective therapeutic or approved human vaccine exist.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 25, 2021
- Source ID
- 10.1186/s13578-021-00732-z
Entities
People
- Adeyemi A. Olanrewaju
- Christine A. Brantner
- Emanuel F. Petricoin
- Farhang Alem
- Fatah Kashanchi
- Graham Matulis
- Heather E. Hobbs
- Lance A. Liotta
- Massimo Caputi
- Noor Ahsan
- Ramin M Hakami
- Samson Omole
- Sina Bavari
- Weidong Zhou
- Yuntao Wu
Organizations
- George Mason University College of Science
- National Institutes of Health
- United States Army Medical Research and Development Command