Genetic and metabolic links between the murine microbiome and memory
Abstract
Recent evidence has linked the gut microbiome to host behavior via the gut–brain axis [1–3]; however, the underlying mechanisms remain unexplored. Here, we determined the links between host genetics, the gut microbiome and memory using the genetically defined Collaborative Cross (CC) mouse cohort, complemented with microbiome and metabolomic analyses in conventional and germ-free (GF) mice.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 16, 2020
- Source ID
- 10.1186/s40168-020-00817-w
Entities
People
- Antoine M Snijders
- B. Y. Loulou Peisl
- Chenhan Zhong
- Colin J. Brislawn
- David W. Threadgill
- Dehong Hu
- Galya Orr
- Hang Chang
- Janet K Jansson
- Jian-Hua Mao
- Paul Wilmes
- Sarah Fansler
- Sasha Langley
- Susan E. Celniker
- Thomas O. Metz
- Yan-xia Zhou
- Young-mo Kim
- Yunshan Wang
Organizations
- Lawrence Berkeley National Laboratory
- Office of Naval Research Global
- Pacific Northwest National Laboratory