Integrating phosphoproteomics into the clinical management of prostate cancer
Abstract
Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcriptomic approaches. Phosphoproteomics could potentially aid drug development in clinical trial design as well as provide utility for oncologists in the personalized therapeutic management of individual cancers through identifying novel biomarkers and druggable targets. Rapid advancement of targeted mass spectrometry platforms is underway to integrate phosphoproteomic technology with genomic assays to soon translate this information into the cancer clinic.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 14, 2017
- Source ID
- 10.1186/s40169-017-0138-5
Entities
People
- Justin M Drake
- Larry C Cheng
- Shridar Ganesan
- Victor M Tan
Organizations
- National Cancer Institute
- National Institute of General Medical Sciences
- New Jersey Health Foundation
- Prostate Cancer Foundation
- Rutgers University
- Rutgers University–New Brunswick
- The Breast Cancer Research Foundation
- United States Department of Defense
- Val Skinner Foundation