Successful treatment of acute B lymphoblastic leukemia relapse in the skin and testicle by anti-CD19 CAR-T with IL-6 knocking down: a case report
Abstract
Extramedullary relapse is an important cause of treatment failure among patients with acute lymphoblastic leukemia (ALL). This type of relapse is commonly observed in the central nervous system, while it is rare in the testicles and skin. Chimeric antigen receptor-modified T cell (CAR-T) therapy targeting CD19 has shown to be a beneficial treatment approach for relapsed/refractory B cell acute lymphoblasticleukemia (r/r B-ALL). Yet, few studies have reported data regarding the treatment of extramedullary B-ALL relapse, especially both in skin and testicle, with CAR-T therapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 06, 2020
- Source ID
- 10.1186/s40364-020-00193-5
Entities
People
- Ai-ning Sun
- De-pei Wu
- Hai-xia Zhou
- Hua Tang
- Jin Wang
- Li-Yun Chen
- Li-qing Kang
- Yao Zhou
- Ze-fa Liu
Organizations
- National Natural Science Foundation of China