Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease
Abstract
Autosomal-dominant Alzheimer's disease (ADAD) is caused by pathogenic mutations inAPP,PSEN1, andPSEN2, which usually lead to an early age at onset (< 65). Circular RNAs are a family of non-coding RNAs highly expressed in the nervous system and especially in synapses. We aimed to investigate differences in brain gene expression of linear and circular transcripts from the three ADAD genes in controls, sporadic AD, and ADAD.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 04, 2022
- Source ID
- 10.1186/s40478-022-01328-5
Entities
People
- Abdallah Eteleeb
- Alison Goate
- Carlos Cruchaga
- Chengjie Xiong
- Ciyang Wang
- Curtis Ebl
- Dominantly Inherited Alzheimer Network
- Eric Mcdade
- Fengxian Wang
- Helena Chui
- Hsiang-han Chen
- Jasmeer Chhatwal
- Joanne Norton
- John C. Morris
- John P Budde
- Kristy Bergmann
- Laura Ibanez
- Maria Victoria Fernandez
- Martin Farlow
- Oscar Harari
- Peter R Schofield
- Randall J. Bateman
- Richard J Perrin
Organizations
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Brain Canada Foundation
- BrightFocus Foundation
- Canadian Institutes of Health Research
- Carlos III Health Institute
- Fonds de Recherche du Québec Santé
- Foundation for the National Institutes of Health
- German Center for Neurodegenerative Diseases
- Japan Agency for Medical Research and Development
- Korea Health Industry Development Institute
- National Institute on Aging
- United States Department of Defense