Pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solution in open fractures (Aqueous-PREP): the feasibility of a cluster randomized crossover study
Abstract
Preoperative antiseptic skin solutions are used prior to most surgical procedures; however, there is no definitive research comparing infection-related outcomes following use of the various solutions available to orthopedic trauma surgeons. The objective of this pilot study was to test the feasibility of a cluster randomized crossover trial that assesses the comparative effectiveness of a 10% povidone-iodine solution versus a 4% chlorhexidine gluconate solution for the management of open fractures.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 01, 2021
- Source ID
- 10.1186/s40814-021-00800-8
Entities
People
- Andrea Howe
- Brad Petrisor
- Franca Mossuto
- Gerard P Slobogean
- Haley K. Demyanovich
- Herman S. Johal
- Jordan Leonard
- Lehana Thabane
- Megan Camara
- Mohit Bhandari
- Nathan N. O’hara
- Paige Guyatt
- Robert V. O'toole
- Shannon Dodds
- Sheila Sprague
- Sofia Bzovsky
- The Prep-it Investigators
- Uyen Nguyen
Organizations
- Canadian Institutes of Health Research
- United States Department of Defense