Mineral deposition and vascular invasion of hydroxyapatite reinforced collagen scaffolds seeded with human adipose-derived stem cells
Abstract
Collagen-based scaffolds reinforced with hydroxyapatite (HA) are an attractive choice for bone tissue engineering because their composition mimics that of bone. We previously reported the development of compression-molded collagen-HA scaffolds that exhibited high porosity, interconnected pores, and mechanical properties that were well-suited for surgical handling and fixation. The objective of this study was to investigate these novel collagen-HA scaffolds in combination with human adipose-derived stem cells (hASCs) as a template for bone formation in a subcutaneous athymic mouse model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 17, 2019
- Source ID
- 10.1186/s40824-019-0167-9
Entities
People
- Diane R. Wagner
- Glen L. Niebur
- Holly E. Weiss-bilka
- Joshua A. Gargac
- Matthew J. Meagher
- Ryan K. Roeder
Organizations
- Indiana University – Purdue University Indianapolis
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- University of Mount Union
- University of Notre Dame