Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation
Abstract
Electrical stimulation of peripheral nerves is a widely used technique to treat a variety of conditions including chronic pain, motor impairment, headaches, and epilepsy. Nerve stimulation to achieve efficacious symptomatic relief depends on the proper selection of electrical stimulation parameters to recruit the appropriate fibers within a nerve. Recently, electrical stimulation of the vagus nerve has shown promise for controlling inflammation and clinical trials have demonstrated efficacy for the treatment of inflammatory disorders. This application of vagus nerve stimulation activates the inflammatory reflex, reducing levels of inflammatory cytokines during inflammation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 10, 2020
- Source ID
- 10.1186/s42234-020-00042-8
Entities
People
- Chad Bouton
- Emily Battinelli Masi
- Eric H. Chang
- Gavin H. Imperato
- Harold A. Silverman
- Justin E. Newman
- Kevin J. Tracey
- Meghan E. Addorisio
- Sangeeta S Chavan
- Timir Datta-chaudhuri
- Téa Tsaava
Organizations
- Defense Advanced Research Projects Agency
- National Institute of General Medical Sciences