The gut microbiome changes in wild type and IL-18 knockout mice after 9.0 Gy total body irradiation
Abstract
Recent studies have shown that gut microbiome plays important roles in response to radiation exposure. IL-18, an inflammatory cytokine, is highly elevated in mice, mini-pigs and nonhuman primates after radiation exposure. Blocking IL-18 using its endogenous binding protein (IL-18BP) increases mice survival after radiation exposure by decreasing bone marrow interferon-gamma levels.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 07, 2023
- Source ID
- 10.1186/s42523-023-00262-8
Entities
People
- Alex Zizzo
- Bin Lin
- Li Wang
- Lisa Hull
- Mang Xiao
- Min Zhai
- Wanchang Cui
Organizations
- Armed Forces Radiobiology Research Institute