Metabolic Dysregulation Controls Endocrine Therapy–Resistant Cancer Recurrence and Metastasis
Abstract
Cancer recurrence and metastasis involves many biological interactions, such as genetic, transcription, environmental, endocrine signaling, and metabolism. These interactions add a complex understanding of cancer recurrence and metastatic progression, delaying the advancement in therapeutic opportunities. We highlight the recent advances on the molecular complexities of endocrine-related cancers, focusing on breast and prostate cancer, and briefly review how endocrine signaling and metabolic programs can influence transcriptional complexes for metastasis competence. Nuclear receptors and transcriptional coregulators function as molecular nodes for the crosstalk between endocrine signaling and metabolism that alter downstream gene expression important for tumor progression and metastasis. This exciting regulatory axis may provide insights to the development of cancer therapeutics important for these desensitized endocrine-dependent cancers.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 03, 2019
- Source ID
- 10.1210/en.2019-00097
Entities
People
- Malachi A Blundon
- Subhamoy Dasgupta
Organizations
- National Cancer Institute
- Roswell Park Comprehensive Cancer Center
- Susan G. Komen for the Cure
- United States Department of Defense