Chronic Ventricular Cerebrospinal Fluid Sampling, Drug Injections, and Pressure Monitoring Using Subcutaneous Reservoirs in Monkeys
Abstract
Animal models enabling reliable access to ventricular cerebrospinal fluid (CSF) are crucial to the study of neuropharmacological and neurotoxicological effects of cytotoxic agents used to treat central nervous system neoplasms. This investigation concludes that 4th ventricular catheterization using subcutaneous CSF reservoirs in rhesus monkeys: (a) provides chronic access to sterile CSF without chronic immobilization, (b) enables mixing of injected drugs with lateral ventricular CSF, (c) permits sensitive monitoring of intraventricular pressure and (d) does not produce tissue damage during cannula implantation or breakdown of the blood-brain barrier.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 1977
- Source ID
- 10.1227/00006123-197709000-00009
Entities
People
- Ayub K. Ommaya
- David G. Poplack
- James H. Wood
- Neal E. Gunby
- William J. Flor
Organizations
- National Cancer Institute
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health