Cortical interneuron development: a tale of time and space
Abstract
Cortical interneurons are a diverse group of neurons that project locally and are crucial for regulating information processing and flow throughout the cortex. Recent studies in mice have advanced our understanding of how these neurons are specified, migrate and mature. Here, we evaluate new findings that provide insights into the development of cortical interneurons and that shed light on when their fate is determined, on the influence that regional domains have on their development, and on the role that key transcription factors and other crucial regulatory genes play in these events. We focus on cortical interneurons that are derived from the medial ganglionic eminence, as most studies have examined this interneuron population. We also assess how these data inform our understanding of neuropsychiatric disease and discuss the potential role of cortical interneurons in cell-based therapies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2017
- Source ID
- 10.1242/dev.132852
Entities
People
- Daniel Vogt
- Jia Sheng Hu
- John Rubenstein
- Magnus Sandberg
Organizations
- Brain & Behavior Research Foundation
- National Institute of Mental Health
- Simons Foundation
- Swedish Research Council
- Swedish Society for Medical Research
- United States Department of Defense
- University of California