Developmentally inspired human ‘organs on chips’
Abstract
Although initially developed to replace animal testing in drug development, human ‘organ on a chip’ (organ chip) microfluidic culture technology offers a new tool for studying tissue development and pathophysiology, which has brought us one step closer to carrying out human experimentation in vitro. In this Spotlight article, I discuss the central role that developmental biology played in the early stages of organ-chip technology, and how these models have led to new insights into human physiology and disease mechanisms. Advantages and disadvantages of the organ-chip approach relative to organoids and other human cell cultures are also discussed.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 18, 2018
- Source ID
- 10.1242/dev.156125
Entities
People
- Donald E. Ingber
Organizations
- AstraZeneca
- Defense Advanced Research Projects Agency
- Gates Foundation
- Harvard Medical School
- Harvard University
- National Institutes of Health
- Taiwan Food and Drug Administration