Nuclear pore complexes in development and tissue homeostasis
Abstract
Nuclear pore complexes are multiprotein channels that span the nuclear envelope, which connects the nucleus to the cytoplasm. In addition to their main role in the regulation of nucleocytoplasmic molecule exchange, it has become evident that nuclear pore complexes and their components also have multiple transport-independent functions. In recent years, an increasing number of studies have reported the involvement of nuclear pore complex components in embryogenesis, cell differentiation and tissue-specific processes. Here, we review the findings that highlight the dynamic nature of nuclear pore complexes and their roles in many cell type-specific functions during development and tissue homeostasis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2020
- Source ID
- 10.1242/dev.183442
Entities
People
- Maximiliano D'Angelo
- Stephen Sakuma
- Valeria Guglielmi
Organizations
- American Cancer Society
- National Institutes of Health
- Sanford Burnham Prebys Medical Discovery Institute
- United States Department of Defense